在控制体重,葡萄糖代谢和猪肠道微生物群方面,ForePass的表现优于Semaglutide
Sara Russo1, Luca Proto1, Manoel Galvao Neto2,3
1Institute of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Diabetes, obesity & metabolism
|September 30, 2025
概括
在猪中,ForePass是一种无切口的内镜装置,显著改善了胰岛素敏感性,并比Semaglutide更有效地减少了体重增加. 这种新的疗法对肥胖和2型糖尿病管理有前途.
科学领域:
- 代谢性疾病研究研究.
- 内镜减肥疗法 内镜减肥疗法
- 药理干预措施 药理干预措施
背景情况:
- 肥胖和2型糖尿病需要有效的治疗策略.
- 目前的治疗方法包括药物和手术选择,有效性和侵入性各不相同.
- 内镜装置提供了一个不那么侵入性的替代方案,模仿手术结果.
研究的目的:
- 评估ForePass新型内镜装置在生长猪中的代谢功效.
- 为了比较ForePass在改善胰岛素敏感性 (SI) 上的优势.
- 评估二次结果,包括体重增加,葡萄糖代谢,代谢组和肠道微生物群.
主要方法:
- 一项为期30天的研究涉及12只Landrace年轻猪,分为三个组:ForePass,Semaglutide和假内镜.
- 使用稳定同位素标记物的口服葡萄糖耐受性测试 (OGTT) 用于评估肝脏葡萄糖处置.
- 测量包括体重,胰岛素敏感性 (SI),葡萄糖出现率 (Ra),内源性葡萄糖生产 (EGP),血代谢量和便微生物群分析.
主要成果:
- 与塞马格卢泰德和假药相比,ForePass显著改善了胰岛素敏感性 (SI).
- 使用ForePass (4%) 的体重增加明显降低,而使用Semaglutide (36%) 和假药 (47%) 的体重增加明显降低 (p <0.0001).
- 福尔帕斯对排放指数 (DI),葡萄糖Ra,EGP以及有益的肠道细菌 (Akkermansia muciniphila) 的增加表现出优异的效果.
结论:
- 与塞马格卢提德相比,ForePass实现了更好的胰岛素敏感性和体重管理结果.
- 该装置表现出明显的代谢效应,包括改善葡萄糖的处置,以及对代谢和微生物群的有利变化.
- ForePass为肥胖和2型糖尿病提供了一个有希望的,可逆的,无切口的内镜治疗方法,弥合了药物和手术之间的差距.
相关概念视频
Glucagon-like Receptor Agonists
848
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
848
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
525
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
525
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
247
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
247
Oral Hypoglycemic Agents: Biguanides and Glitazones
585
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
585
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
169
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
169
Oral Hypoglycemic Agents: Sulfonylureas
781
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
781


