在口腔白血病中癌症特征表达:系统性审查和元分析
I González-Ruiz1, P Ramos-García2,3, H Boujemaoui-Boulaghmoudi2,3
1Pius de Valls Hospital, Tarragona, España.
Oral diseases
|September 30, 2025
概括
口腔白血病 (OL) 具有持续增殖,上皮 - 介质细胞过渡 (EMT) 和免疫逃避的特征,更有可能转化为口腔癌. 这些分子事件是恶性转变风险的关键指标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 口腔病理学 口腔病理学
背景情况:
- 口腔白血病 (OL) 是一种癌前病变,有恶性转变为口腔癌的风险.
- 了解推动这种转变的分子事件对于早期检测和干预至关重要.
研究的目的:
- 评估老年人癌症特征的表达.
- 识别与OL恶性转变相关的早期分子事件.
- 根据分子标记来确定OL恶性转变的概率.
主要方法:
- 纵向队列研究的系统审查和元分析.
- 搜索了Embase,MEDLINE/PubMed,Scopus和科学网络的数据库.
- 在60项研究中的9758名OL中使用免疫组织化学评估了68种生物标志物的表达.
主要成果:
- 持续扩散在OL中很常见 (56.3%) 并与恶性转变显著相关 (RR=1.92).
- 在37.3%的OL中观察到表皮-介质细胞过渡 (EMT),与口腔癌有很强的联系 (RR=3.43).
- 免疫逃避机制也过度表达 (35.8%) 并与口腔癌的进展相关 (RR=3.65). 基因组不稳定性标记物也与此有关.
结论:
- 呈现EMT和免疫逃避机制的超增殖性OL病变具有显著增加恶性转变的风险.
- 这些发现突出了涉及口腔致癌的关键致癌途径.
- 识别OL中的这些分子变化可以帮助预测恶性转变风险.
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