低风险,早期乳腺癌的放射治疗缺失:一个单中心,现实世界的比较分析
Youngju Song1, Sae Byul Lee2, Su Ssan Kim1
1Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Radiation oncology journal
|September 30, 2025
概括
对于低风险的早期乳腺癌患者,省略辅助放射治疗并没有增加疾病复发或影响生存率. 对精心挑选的患者群体需要进行进一步的研究.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 辅助放射治疗 (RT) 是早期乳腺癌的标准治疗方法.
- 它在低风险,早期疾病中的作用需要进一步澄清.
- 优化治疗降级对于减少长期副作用至关重要.
研究的目的:
- 为了比较接受辅助RT的低风险早期乳腺癌患者与未接受辅助RT的患者之间的治疗结果.
- 评估RT缺失对疾病复发率和生存率的影响.
主要方法:
- 对pT1N0/Nx,等级1-2,激素受体阳性,HER2阴性,Ki-67 ≤20%乳腺癌的绝经后妇女的回顾性分析.
- 患者在2010-2020年间接受了乳腺保护手术和辅助内分泌疗法.
- 评估结果包括疾病复发的累积发病率,局部区域复发,整体存活率和乳腺癌特异性存活率.
主要成果:
- 包括742名患者:707人接受了RT (PORT组),35人没有RT.
- 随访时间中位数:60个月 (PORT) 和52个月 (RT遗漏).
- 疾病复发的5年累计发病率:1.28% (PORT) 与0% (RT遗漏). 在RT省略组中没有地方区域的复发.
结论:
- 低风险,早期乳腺癌患者的疾病复发率和存活率相似,无论辅助RT状态如何.
- 对于精心挑选的患者来说,RT省略可能是一个可行的选择.
- 需要进一步研究RT在特定人群中的降级.
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