一种新的生物降解用于消化道 - - 熊降解研究
Anna Wiebe1, Wolfram Lamadé2, Jonas Apitzsch3
1Department of Vascular Surgery, Hospital Esslingen, Esslingen, Germany.
概括
一种新的聚氨粘合剂,VIVO 120TM,由于其对消化液的抗性,对胃肠道手术有很大的希望. 虽然它膨胀,但它保持了结构完整性,并在临床前试验中证明了有效的密封性.
科学领域:
- 生物材料科学 生物材料科学
- 手术创新 在外科创新.
- 胃肠病学 胃肠病学
背景情况:
- 理想的胃肠道粘合剂需要灵活性,透明度,生物降解性和对消化液的抗性.
- 传统的凝粘合剂迅速溶解,限制了它们在消化道中的使用.
- 新型聚氨粘合剂VIVO 120TM旨在克服这些局限性.
研究的目的:
- 评估基于聚氨的粘合剂VIVO 120TM的性能和安全性.
- 为了评估其在各种模拟的胃肠道条件下对降解的抵抗力.
- 确定其适用于胃和胰腺外科应用的适用性.
主要方法:
- 维沃120TM在水,酸和胰腺酶溶液中进行了21天的测试.
- 计算机断层扫描 (CT) 监测了身体变化,并对结构和体重变化进行了宏观评估.
- 在使用破裂压力测试的猪尸体中评估了处理和密封的有效性.
主要成果:
- 维沃120TM表现出显著的胀 (长度增加高达58%) 但保持了结构完整性.
- 体重增加很大 (高达226%),大多数胀发生在24小时内.
- 粘合剂在猪模型中表现出良好的处理性,透明度和有效密封度高达40 mmHg.
结论:
- 维沃120TM对酸性和酶性降解具有出色的抗性,适用于胃和胰腺手术.
- 它的灵活性,透明度和可用性有利于组织粘附.
- 潜在的胀需要在狭窄的外科空间中仔细考虑.
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