分析关于甲基酸盐的撤回出版物
Burhan Fatih Kocyigit1, Kairat Zhakipbekov2, Marlen Yessirkepov3,4
1Department of Physical Medicine and Rehabilitation, University of Health Sciences, Adana City Research and Training Hospital, Adana, Türkiye. bfk2701@hotmail.com.
Journal of Korean medical science
|September 30, 2025
概括
科学完整性受到数据问题和甲基酸盐研究中的欺诈威胁. 这项研究分析了36篇撤回的论文,突出了改善研究伦理和同行评审的必要性,以保持对临床建议的信任.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 科学完整性 科学完整性
- 图书统计学 图书统计学
背景情况:
- 甲托雷克萨特 (MTX) 是一种广泛用于风湿病学,瘤学和皮肤病学的抗叶酸剂.
- 科学撤回对于纠正错误,伦理违规和发表的研究数据伪造至关重要.
- 本研究调查了涉及甲状腺素 (MTX) 的撤回出版物,以确定趋势,原因和影响.
研究的目的:
- 综合分析与甲索 (MTX) 相关的撤回出版物.
- 检测趋势,确定撤回的原因,并评估撤回的MTX研究的潜在影响.
- 为提高MTX研究科学完整性的战略提供信息.
主要方法:
- 采用了一种描述性的横截面研究设计.
- 在PubMed中搜索了没有日期限制的撤回的MTX出版物.
- 收集和分析了包括引用指标和Altmetric注意力得分 (AAS) 在内的图书统计数据.
主要成果:
- 有36篇与MTX相关的论文被认定为被撤回的.
- 撤回的主要原因包括数据问题 (n=15),欺诈 (n=11) 和同行评审操纵 (n=10).
- 中国 (n=14) 的撤回人数最多,其次是美国 (n=6) 和埃及 (n=3).
结论:
- 数据完整性问题,欺诈和同行评审操纵在MTX研究中构成重大挑战.
- 特定国家的高收回率强调了促进研究伦理和科学诚信的必要性.
- 加强同行评审,提高数据透明度和加强出版后评估对于保持对临床建议的信任至关重要.
相关概念视频
Therapeutic Drug Monitoring: Affecting Factors
201
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
201
Phase II Reactions: Methylation Reactions
676
Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
676
Therapeutic Drug Monitoring: Drug Analysis Methods
179
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
179
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
493
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
493


