相关实验视频

Updated: Jan 16, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

免疫检查点分子印度莱胺2,3-二氧化酶1 (IDO1) 在淋巴瘤亚型中表达具有和没有爱斯坦-巴尔病毒

Kala Gnanasekaran Kiruthiga¹, Sheren Younes², Brindhavan N Jaeger

¹Department of Pathology, King Edward Memorial Hospital, Pune, India.

Applied immunohistochemistry & molecular morphology : AIMM

|September 30, 2025

概括

印度列胺2,3-二氧化酶1 (IDO1) 在各种淋巴瘤中表达,与爱斯坦-巴尔病毒 (EBV) 阳性相关. 这个免疫调节器是免疫调节器.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
病理学病理学病理学

背景情况:

氨酸2,3-二氧化酶1 (IDO1) 是一种关键的免疫调节剂,与瘤免疫逃生有关.
在各种固体瘤和淋巴瘤的瘤微环境中观察到IDO1的表达,特别是与爱斯坦-巴尔病毒 (EBV) 相关的瘤.
对IDO1抑制剂的有前途的临床试验结果突出显示了针对该途径的治疗潜力.

研究的目的:

评估一大群淋巴瘤的IDO1表达,包括与EBV相关的病例.
研究不同淋巴瘤亚型中的IDO1表达和EBV状态之间的相关性.
探索IDO1作为在侵袭性和耐性淋巴瘤的治疗点的潜力.

主要方法:

优化免疫组织化学试验,以实现强大的IDO1染色.
在455例淋巴瘤病例中评估IDO1表达,包括154例EBV阳性病例.
利用多重免疫光学来精确地定位瘤微环境中的IDO1蛋白.

主要成果:

在多种淋巴瘤亚型中检测到IDO1的表达,包括经典霍奇金淋巴瘤 (CHL),扩散性大B细胞淋巴瘤 (DLBCL),淋巴增殖性疾病 (LPD-PT),外节NK/T细胞淋巴瘤 (ENKTL) 和ALK阴性形大细胞淋巴瘤 (ALCL).
在CHL,LPD-PT和ENKTL的IDO1表达和EBV阳性之间发现了显著的相关性.
在ALCL中IDO1表达主要观察到ALK阴性病例,与ALK状态相关.

结论:

IDO1的表达与EBV阳性淋巴瘤有显著的关联.
IDO1也表达在EBV阴性淋巴瘤中,包括攻击性和耐火性亚型.
这些发现支持IDO1向免疫检查点抑制作为各种淋巴瘤的治疗策略的潜力.

关键词:

爱斯坦-巴尔病毒病毒.标签: 标签: IDO1 标签: IDO1 标签: IDO1 免疫检查点是一个检查点.淋巴瘤淋巴瘤是什么瘤微环境是一个微环境.

更多相关视频

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

相关概念视频

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...