大麻使用障碍的药物治疗方法
Francesca Spiga1,2, Thomas Parkhouse1,2, Victor M Tang3,4,5,6
1NIHR Bristol Evidence Synthesis Group, University of Bristol, Bristol, UK.
The Cochrane database of systematic reviews
|September 30, 2025
概括
目前,对于大麻使用障碍,还没有批准的药物治疗方法. 这次审查发现各种药物的疗效证据有限,这表明它们仍然是这种疾病的实验性治疗方法.
科学领域:
- 成 药物 药物 药物 药物
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 大麻使用障碍 (CUD) 是一个普遍的全球健康问题.
- 目前没有药物疗法被批准用于CUD治疗.
- 本综述是之前关于CUD药物疗法的Cochrane综述的更新.
研究的目的:
- 评估CUD药物疗法的有效性和安全性.
- 为了将药物相互比较,安慰剂或支持性护理.
- 评估对大麻戒断症状,戒断和减少的影响.
主要方法:
- 随机对照试验 (RCT) 和准RCT的系统审查和元分析.
- 在主要数据库 (CENTRAL,MEDLINE,Embase,PsycINFO) 中于2024年5月更新的搜索.
- 包括37个RCT,3201名参与者,主要是成年人,男性占多数.
主要成果:
- 有限的证据表明,与安慰剂相比,THC,N-乙半氨酸,大麻醇或抗发作药/情绪稳定剂的戒断率没有显著增加.
- 在大多数活性治疗和安慰剂中,不良事件发生率相似.
- 抗药和情绪稳定剂显示,由于不良反应,治疗中止的可能性更高.
结论:
- 现有的CUD药物疗法显示有效性的证据不完全,应该被认为是实验性的.
- 对许多结果的证据质量很低或非常低.
- 抗药和情绪稳定剂可能具有有限的治疗价值,这是由于与不良事件相关的戒断增加.
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