在CHAMACOS研究中,从出生到青春期的累积表观遗传衰老以及与心脏代谢健康的潜在关联
Saher Daredia1, Corinne A Riddell1,2, Dennis Khodasevich3
1Division of Epidemiology, School of Public Health University of California Berkeley CA USA.
Journal of the American Heart Association
|September 30, 2025
概括
从出生到18岁的累积表观遗传衰老 (EA) 预测了年轻人的心脏代谢健康状况. 这一发现突显了表观遗传钟作为早期生物标志物的潜力,用于预防未来疾病的干预.
科学领域:
- 表观遗传学和发育生物学
- 心血管和新陈代谢健康
- 生物标志物发现发现
背景情况:
- 表观遗传修饰,如DNA甲基化 (DNAm),与生物衰老有关,可能表明未来心脏代谢疾病的风险.
- 以前的研究主要集中在老年人身上,忽视了心脏代谢健康的早期起源.
研究的目的:
- 研究从出生到18岁的累积表观遗传衰老 (EA) 与18岁心脏代谢健康指标之间的关联.
- 探索生命历程表观遗传钟作为早期生命生物标志物的实用性.
主要方法:
- 利用来自CHAMACOS研究的378名参与者的数据,从出生到18岁时反复测量DNAm.
- 计算了四个表观遗传衰老 (EA) 生物标志物:Horvath,皮肤和血液,内在表观遗传年龄和DNAm端粒长度 (DNAmTL).
- 开发了一种累积EA的新测量方法,并使用回归模型来评估18岁时与心脏代谢健康指标的关联.
主要成果:
- 累积EA增加与多个生物标志物 (霍尔瓦斯,皮肤和血液,内在表观遗传年龄) 的肥胖风险增加有关.
- DNAm端粒长度 (DNAmTL) 显示肥胖风险降低.
- 累积EA与18岁时不良心脏代谢标志物相关,包括更高的BMI,腰围,身体脂肪百分比,血压和休息心率.
结论:
- 整个童年累积表观遗传衰老是年轻成人心脏代谢健康的重要预测因素.
- 表观遗传钟为早期健康轨迹和以后心脏代谢疾病的潜在风险提供了宝贵的见解.
- 这些发现强调了生命早期干预的重要性,这些干预由生命历程表观遗传生物标志物告知.
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