2010年至2021年间, Carotid Plaque 呈现出更多不稳定的特征,在此前十年的稳定之后
Barend M Mol1, Tetiana Motsak1,2, Joost K R Hoekstra1,3
1Department of Vascular Surgery UMC Utrecht Utrecht Netherlands.
Journal of the American Heart Association
|September 30, 2025
概括
动脉样硬化性动脉斑在2010-2021年间呈现出越来越多的破坏稳定的特征,与之前的趋势不同. 这项研究发现没有进一步的斑块稳定,这表明过去十年来可能会向更脆弱的斑块转移.
科学领域:
- 心血管研究研究心血管研究
- 病理学 病理学 病理学
- 生物材料科学 生物材料科学
背景情况:
- 之前的研究表明,从2002年到2011年,动脉样硬化性大脑动脉板的破坏性特征趋于下降.
- 这一趋势与西欧改善药物坚持和降低心血管死亡率相吻合.
- 目前的研究旨在确定这些斑块稳定趋势是否持续到最近十年.
研究的目的:
- 在过去十年 (2010-2021) 中,研究动脉样硬化性心血管斑块组织学特征的时间依赖性变化.
- 为了比较当前的斑块特征与前一个时期 (2002-2011) 的数据.
- 评估斑块稳定特征是否继续增加或是否出现不稳定迹象.
主要方法:
- 使用Athero-Express生物库对1277个动脉样硬化斑块的组织学特征进行分析,这些斑块来自接受动脉内关节切除术 (2010-2021) 的患者.
- 在两年间对斑块特征的时间依赖性变化的评估.
- 与1660名患者之前的队列 (2002-2011) 结果的比较.
主要成果:
- 2010-2021年期间,易受损伤的斑块特征显著增加,包括大脂质核,斑块内出血,巨细胞和化.
- 调整后的分析显示,每2年增加的化 (OR=1.204),内出血 (OR=1.358),大脂核 (OR=1.271) 和巨细胞 (OR=1.366) 的几率增加.
- 在这两项研究期间,他类药物的使用量都增加了,但在过去十年中,斑块的脆弱性增加了.
结论:
- 2010年至2021年期间,阴道动脉样硬化斑块中增加斑块稳定特征的趋势没有得到支持.
- 与之前的发现相反,最近的队列表现出表明斑块不稳定的特征.
- 这些结果表明,以前观察到的斑块稳定趋势可能会逆转.
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