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Updated: Jan 16, 2026

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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使用虚拟患者来评估双特异剂的剂量策略,使用钟形有效率曲线

Jana L Gevertz1, Irina Kareva2,3

  • 1Department of Mathematics and Statistics, The College of New Jersey, Ewing, New Jersey, USA.

CPT: pharmacometrics & systems pharmacology
|September 30, 2025
PubMed
概括

基于三元体的双特异抗体的剂量选择是具有挑战性的,因为钟形的疗效. 药理动力学/药理动力学模型表明,目前的特克利斯塔马布剂量对许多患者来说是最佳的,从而使生物标志物引导的分层成为可能.

关键词:
在B细胞成熟抗原.钟形的疗效曲线是一个钟形的疗效曲线.两种特定的物种.患者分层是患者的分层.半个性化药物 半个性化药物德克里斯塔马巴巴 的意思虚拟人口是虚拟的人口.

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