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Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Nose and Nasal Cavity01:24

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The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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鼻腔肉瘤管理:一个国际共识声明

Alessandro Vinciguerra1, Francesca Caspani2, Marco Valentini1

  • 1Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.

International forum of allergy & rhinology
|September 30, 2025
PubMed
概括

鼻肉瘤,罕见的头癌,需要组织学特定的治疗. 专家的共识强调需要个性化,多学科的管理,因为不同的亚型和复杂的解剖学.

关键词:
尤文肉瘤 (Ewing Sarcoma) 是一种癌症.血管瘤是一种血管瘤.双种类型的鼻肉瘤这种疾病是chondrosarcoma.雷奥米奥萨科马 (leiomyosarcoma) 是一种癌症.恶性外围神经膜瘤 恶性外围神经膜瘤骨质肉瘤是骨质肉瘤的一种疾病.拉布多米索科马 (rhabdomyosarcoma) 是一种肌肉癌.这种类型的鼻肉瘤 (sinonasal sarcomas).突性肉瘤 (Synovial Sarcoma) 是一个突性肉瘤.

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科学领域:

  • 在瘤学瘤学.
  • 头部和部手术 头部和部手术
  • 罕见的癌症 罕见的癌症

背景情况:

  • 鼻肉瘤很少见,占<7%的头肉瘤.
  • 组织学复杂性需要专门的多模式治疗 (手术,放射,化疗).
  • 这项研究旨在就鼻肉瘤管理原则达成共识.

研究的目的:

  • 收集国际专家关于鼻肉瘤管理的意见.
  • 定义治疗这些罕见恶性瘤的共同原则.
  • 解决对标准化但又个性化的治疗策略的需求.

主要方法:

  • 修改后的Delphi方法涉及一个七步的国际共识过程.
  • 开发了62份关于鼻肉瘤管理的陈述.
  • 对44名来自多个大陆的专家进行了两轮调查.

主要成果:

  • 治疗方法因组织学而异:对双型,冠状腺,状腺和肌纤维肉瘤进行前期手术.
  • 化疗,可能与放射治疗一起,通常是优选的Ewing肉瘤和狂宫肌肉瘤.
  • 血管肉瘤,脂肉瘤,MPNST,骨肉瘤和突肉瘤的治疗方式不太规范,需要逐个评估.

结论:

  • 以组织学为导向的方法对于确定鼻肉瘤的初始治疗至关重要.
  • 尽管有结构化管理,但预后在各个亚型之间存在显著差异.
  • 在转诊中心进行多学科评估对于管理这些复杂,多样化的罕见癌症至关重要.