药物诱导的周眼和眼睛表面疾病:EAACI立场论文
Andrea Leonardi1, Banu Bozkurt2, Diana Silva3,4,5
1Ophthalmology Unit, Department of Neuroscience, University of Padova, Padova, Italy.
Allergy
|September 30, 2025
概括
药物可能会导致影响眼睛表面 (OS) 的眼部不良反应 (AEs). 本文回顾了药物诱导的副作用,它们的诊断和管理策略,以获得更好的患者结果.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 系统和局部药物可能会导致眼部和眼周的不良反应 (AE).
- 这些副作用范围从轻度到严重,可能导致眼表面 (OS) 损伤或严重并发症.
- 药物诱导的眼部反应被分类为有毒或过敏 (IgE或非IgE介导).
研究的目的:
- 提供药物诱导的眼部副作用的全面概述.
- 详细介绍临床表现,诊断方法和治疗策略.
- 整合有关管理这些疾病的最新文献和临床指南.
主要方法:
- 文献综述和当前临床指南的综合.
- 分析证据,涉及眼部AE的各种药物类别.
- 专注于与生物治疗相关的最新发现.
主要成果:
- 通常涉及的药物包括全身抗生素,抗病毒药物,抗发作药物,抗组胺药物,β-阻断剂,抗精神病药物,抗抑郁药物和异丁氨酸.
- 局部治疗,如抗生素,抗白内障药物,防腐剂和化品也可能导致眼部AE.
- 生物制剂 (例如EGFR抑制剂,dupilumab) 越来越多地与眼睛表面疾病 (如结膜炎,美炎和眼睛干燥) 相关.
结论:
- 药物诱导的眼部副作用是一个重要的临床问题,需要仔细的诊断和管理.
- 了解各种机制和临床表现对于有效治疗至关重要.
- 本综述为临床医生管理与药物相关的眼表面问题患者提供了一个框架.
相关概念视频
01:25Glaucoma: Overview
1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
01:27Open Angle Glaucoma: Treatment
963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
01:17Accessory Structures of the Eye
3.4K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
3.4K
01:28Angle Closure Glaucoma: Treatment
1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K