在运动障碍中神经刺激,从原则到对证据的系统审查
Francesca Proietti1, Matteo Maria Ottaviani2,3, Elisabetta Burchi4,5
1Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy.
Movement disorders : official journal of the Movement Disorder Society
|September 30, 2025
概括
神经刺激 (VNS) 通过改善运动和非运动症状,显示出治疗像帕金森病这样的运动障碍的前景. 非侵入性耳部VNS是一种更安全的替代方案,需要进一步研究.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 迷走神经 (VN) 对于中枢神经系统 (CNS) 和器官之间的双向通信至关重要.
- 神经刺激 (VNS) 正在针对运动障碍 (MDs) 进行研究.
研究的目的:
- 系统地审查VNS在各种运动障碍中的治疗潜力.
- 专注于帕金森病 (PD),帕金森症,基本震 (ET),宫 dystonia (CD) 和图雷特综合征 (TS).
主要方法:
- 在PubMed,科学网络和Scopus (2020-2025) 的系统文献搜索.
- 遵守系统审查和元分析2020指南的首选报告项目.
主要成果:
- 包括32项研究:22项关于PD/帕金森症,6项关于震/ET,2项关于CD,1项关于TS.
- 视觉神经系统改善了运动/非运动症状,增强了突触可塑性,调节了神经递质 (GABA,北上腺素,多巴胺,乙胆),并减少了神经炎症.
- 非侵入性穿皮耳膜VNS (taVNS) 已成为入侵性VNS (iVNS) 的一个有希望的替代品.
结论:
- 在MD中,VNS表现出多模式效应,在PD中具有显著的好处.
- 非侵入性的taVNS提供了一个更安全的治疗选择.
- 需要进行更大规模的随机对照试验,以确认药物的疗效,并优化医疗药师的VNS协议.
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