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保存的基因表达在发育中的可塑性比表达分歧在种类之间的Caenorhabditis Nematodes更为普遍

Athmaja Viswanath¹, Daniel D Fusca¹, John A Calarco²

¹Department of Ecology & Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.

Evolution & development

|September 30, 2025

概括

密切相关的线虫物种C. remanei和C. latens之间的基因表达差异主要是由性别偏差的基因驱动的,特别是在男性中. 组织偏差的基因表达模式在各个物种中仍然在很大程度上保留着.

科学领域:

进化生物学是进化的生物学.
基因组学就是基因组学.
发育生物学是发展生物学.

背景情况:

基因表达调节对生物体发育至关重要,在组织和性别之间有不同的模式.
基因调节的进化变化可以导致特定物种的表达特征,即使在密切相关的物种中也是如此.
了解转录组分歧有助于阐明塑造物种差异的进化过程.

研究的目的:

量化两种Caenorhabditis线虫的姊妹物种中性别和组织偏差的转录组的进化分歧.
识别C. remanei和C. latens.之间具有明显的转录形状的基因组.
调查性别偏差和组织偏差基因在驱动特定物种基因表达中的作用.

主要方法:

来自雄性和雌性C. remanei和C. latens的生殖腺和体内组织的比较转录学.
差异基因表达分析以确定显著的表达变化.
共同表达网络分析以探索基因调节关系.

主要成果:

在C. remanei和C. latens之间观察到广泛的转录组分歧,尽管有形态和发育上的相似之处.
大多数基因在各个组织和性别中都表现出保存表达,这表明了保存的调节机制.
性倾向的基因,特别是男性倾向的基因,对观察到的特定物种的基因表达差异作出了不成比例的贡献.
在物种之间,发育性塑性组织偏差表达特征在很大程度上得到了保留.

结论:

与组织和性别差异相关的共享选择压力似乎在塑造整体转录组概况时超过了特定物种的选择.
男性偏向的基因在驱动这些姐妹线虫物种之间的基因表达分歧方面发挥着不成比例的重要作用.
基因表达的进化分歧,特别是性别偏差表达,即使在非常密切相关的物种之间,也会迅速发生.

关键词:

卡因诺哈比迪斯炎是什么?基因表达的基因表达方式性别偏见的表达方式种类的变化种类的变化组织偏差表达.

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