在结直肠癌查中选择FIT或结直肠镜的基于风险的指导:一个建模研究
Luuk A van Duuren1,2, Jean-Luc Bulliard2, Matthias Harlass1
1Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands.
使用便免疫化学测试 (FIT) 和结肠镜检查,对结肠直肠癌 (CRC) 查的简单基于年龄的指导可以显著增加质量调整寿命年 (QALYs),而不会增加对结肠镜检查的需求.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 卫生经济学 卫生经济学
背景情况:
- 结肠直肠癌 (CRC) 查计划经常提供结肠镜检查和便免疫化学检查 (FIT).
- 在CRC查中优化资源配置至关重要,特别是在结肠镜需求方面.
- 指导策略可以通过引导个人进行适当的测试来提高CRC查的效率.
研究的目的:
- 确定有效的CRC查指导策略,在给定的结肠镜检查需求范围内最大限度地提高质量调整寿命 (QALYs).
- 在瑞士CRC查的背景下,评估基于年龄,基于风险得分和基于FIT的策略.
- 将新策略的效率与参考策略进行比较,例如仅进行结肠镜检查或混合FIT/结肠镜检查.
主要方法:
- 利用瑞士的MISCAN-Colon微型模拟模型来模拟CRC查结果.
- 评估了三种主要策略类型:基于年龄,基于风险得分和基于FIT的转换.
- 我们将这些策略与仅进行结肠镜检查的方法以及在50岁时同等接受FIT/结肠镜检查的策略进行了比较.
主要成果:
- 基于年龄和风险评分的策略,包括基于年龄的切换或在54,64或74岁时进行风险评估,证明了效率.
- 与参考策略相比,这些高效的策略提高了QALYs10.0% (策略1) 和6.7% (策略2),而没有增加结肠镜需求.
- 基于FIT的转换策略被发现是低效的.
结论:
- 通过实施简单的基于年龄的指导来选择FIT和结肠镜,CRC查计划可以提高效率.
- 基于年龄的策略比涉及先前FIT结果或风险评分的复杂方法更有效.
- 这些发现支持在类似于瑞士和美国的项目中优化查资源.
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