在单次CT结肠镜或两年一次的FIT查后,结肠直肠癌和高级腺瘤在SAVE随机对照试验中被发现
Donella Puliti1,2, Lapo Sali3, Mario Mascalchi4
1Department of Epidemiology and Clinical Governance, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Radiology
|September 30, 2025
概括
对于CT结肠镜 (CTC) 的5年查间隔对于结肠直肠癌 (CRC) 检测是适当的. 与两年一次的便免疫化学测试 (FITs) 相比,CTC可能会导致更早的诊断,CRC发病率类似,但晚期腺瘤检测率更高.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 目前的指导方针建议CT结肠镜 (CTC) 的查间隔为5年,查结肠直肠癌 (CRC) 的查间隔为2年,用于便免疫化学测试 (FIT).
- CRC的自然史为这些推的查频率提供了信息.
研究的目的:
- 评估CTC5年查间隔的适当性.
- 与每两年一次的FIT查相比,确定CTC是否与早期的CRC诊断有关.
主要方法:
- 对SAVE随机对照试验的二次分析,该试验涉及14981名年龄在54-65岁之间的参与者.
- 参与者被随机分配到单个CTC检查或三次两年一次的FIT.
- 考克斯回归模型被用来比较CRC和晚期腺瘤 (AdA) 发病率在扩大后的随访后在不同组之间.
主要成果:
- 在CTC和FIT分支之间没有观察到CRC发病率的统计学上显著差异 (调整后的危险比率,0.73;P = .38).
- 所有IV阶段的CRC (n=7) 在FIT手臂中被诊断出.
- 与FIT手臂相比,CTC手臂的晚期腺瘤 (AdA) 发病率明显高 (调整后的危险比,1.46;P = .007).
结论:
- 对CTC的5年查间隔似乎适用于结直肠癌查.
- 与每两年一次的FIT查相比,CTC查可能与早期诊断结直肠瘤有关.
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