暴露于颗粒物和沙尔科毒的情况
Andrew J Ghio1, Spencer A Scott2, Stephen L Tilley3
1US Environmental Protection Agency, Research Triangle Park, NC, USA.
概括
暴露于环境颗粒,如二氧化和金属,与肺癌沙尔科毒症的发展有关. 这种关联表明,在诊断沙尔科毒症时应考虑颗粒暴露.
科学领域:
- 环境医学 环境医学
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
背景情况:
- 沙丘病是一个慢性颗粒性疾病,主要影响肺部.
- 传统上,诊断需要排除颗粒瘤的其他原因.
- 萨尔科病症的异常性质已被研究将其与粒子暴露联系起来所质疑.
研究的目的:
- 为了调查颗粒物暴露和肺部沙尔科毒症之间的关联.
- 审查关于沙尔科毒性病原体的环境因素的现有文献.
主要方法:
- 系统的文献审查.
- 在PubMed/MEDLINE,科学网和TOXNET.NET上进行的搜索.
主要成果:
- 颗粒物可以诱导类似于萨尔科伊多症的颗粒瘤.
- 关键的涉及粒子包括,酸盐,金属,金属氧化物和世界贸易中心的尘埃.
- 这些颗粒在沙尔科毒症的发病过程中起着重要作用.
结论:
- 暴露于颗粒物经常与肺癌型硬化症有关.
- 由于已知的颗粒暴露, Sarcoidosis 的诊断不应被排除在外.
- 环境因素对型硬化症的发展具有重要意义.
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