葡萄糖溶解途径的早期演变,从自营源到葡萄糖原,然后再回到原来的状态
Luca D Modjewski1, Ulrike Johnsen2, Peter Schönheit2
1Institute of Molecular Evolution, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
FEMS microbiology reviews
|September 30, 2025
概括
葡萄糖分解和葡萄糖生成途径是从自营源进化的,葡萄糖分解是以后发生的,用于糖原分解. 这解释了糖代谢酶在 prokaryotes 的多样分布.
科学领域:
- 微生物的新陈代谢
- 进化生化学的进化生化学
- Prokaryotic 的基因组学是什么?
背景情况:
- 碳代谢,包括糖解,葡萄糖生成和糖原代谢,是生命的基础.
- 这些途径在 prokaryotes 的进化历史还没有完全理解.
- 参与葡萄糖合成和分解的酶为早期碳代谢提供了线索.
研究的目的:
- 研究酶在糖溶解,葡萄糖生成和 prokaryotes 中的糖原代谢中的分布和遗传学关系.
- 为了阐明这些代谢途径的进化起源.
主要方法:
- 生物信息分析酶的分布和发育.
- 培养 prokaryotic 基因组的比较基因组学.
主要成果:
- 糖原合成和葡萄糖生成在 prokaryotes 中是普遍的,但糖解不是.
- 糖解路径存在于依赖H2的化学物质,与细胞内存储的糖原利用相关.
- 葡萄糖溶解的演变似乎发生在三个阶段,源自自otrophic 过程.
结论:
- 葡萄糖溶解很可能起源于自身养的环境中的葡萄糖生成.
- 干部糖解的演化先于葡萄糖利用途径.
- 在微生物糖酸盐路径中观察到的酶多样性可以通过自营源来解释,其次是依赖糖原的葡萄糖利用.
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