通过以效果为导向的分析解读来自弹性体的水性液的雌激素活性
Rebecca Süßmuth1, Timothy Rosenberger1, Peter Schweyen1
1Federal Institute of Hydrology, Am Mainzer Tor 1, 56068 Koblenz, Germany.
Environmental science & technology
|September 30, 2025
概括
这项研究确定了4-二烯胺 (4HDPA) 是液中雌激素性的主要原因. 这种N,N'-替代的p-phenylenediamines (PPD) 的转化产物也在河流和溪水中被检测到.
科学领域:
- 环境化学环境化学
- 内分泌学 在内分泌学.
- 分析化学 分析化学
背景情况:
- 替代N,N的p-phenylenediamines (PPD) 是常见的抗臭剂.
- 来自弹性体膜的水性液可能含有生物活性化合物.
- 环境样本中的雌激素活性越来越令人担忧.
研究的目的:
- 为了确定负责弹性体浸出物中雌激素性的特定化合物.
- 为了研究PPD抗臭氧剂的转化产物.
- 量化已识别的化合物对整体雌激素性贡献的数量.
主要方法:
- 以效果为导向的分析结合了高性能薄层染色学 (HPTLC) 和平面酵母雌激素查 (p-YES).
- 使用液体染色学与高分辨率质谱学 (LC-HRMS) 结合的非目标查.
- 通过MS2光谱阐明和图书馆研究来识别化合物.
主要成果:
- 鉴定出4-二烯胺 (4HDPA) 和N--p-基单胺 (QMI) 是转化产物.
- 在酵母雌激素屏幕 (YES) 中,QMI转化为4HDPA.
- 4HDPA被证实是弹性质泄物中雌激素性的主要驱动因素 (120 ± 30%).
- 在河流和溪流水中检测到4HDPA,其度为720 ng/L.
结论:
- 4HDPA是一种新发现的雌激素化合物,起源于PPD抗氧剂.
- 在YES介质中的转化过程可以影响对氧化还原活性化合物的结果.
- 弹性液由于4HDPA的化和形成而构成环境风险.
- 表面水中4HDPA的存在凸显了监测的必要性.
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