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首次直接证实了内神经瘤组织中加速分子衰老的直接证据

Dilaware Khan¹, Xuanchen Li¹, Michael Hewera¹

¹Department of Neurosurgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

|September 30, 2025

概括

血管衰老,以端粒长度衡量,在内动脉瘤组织中加速. 这种分子衰老涉及增加的氧化应激和与炎症相关的通路激活,独立于时间年龄.

科学领域:

血管生物学血管生物学
分子衰老分子衰老
心血管疾病研究研究

背景情况:

心血管疾病的风险随着年龄的增长而升级,促使人们对血管衰老标志物的研究.
当前标记可能不会直接反映真正的血管衰老.
端粒长度提供了直接衡量细胞和血管衰老的指标.

研究的目的:

为了研究内动脉瘤 (IA) 组织中的分子衰老.
量化端粒长度作为IA血管衰老的直接标志物.
探索IA中相关的衰老和炎症途径.

主要方法:

在手术期间切除非患病的对照血管和IA组织 (破裂和未破裂).
在IA和对照组织中测量端粒长度.
对衰老标志物 (Lamin B1,P21),通路激活 (mTOR,NF-κB) 和氧化应激标志物的分析.

主要成果:

与对照人群相比,IA组织的端粒长度显著缩短,不论年龄如何.
在IA组织中,Lamin B1的表达较低,P21的表达较高.
增加mTOR和NF-κB通路的激活,并增加IA组织中的氧化应激.

结论:

内动脉瘤组织表现出加速的分子衰老.
在IA中血管衰老与增加的氧化应激和炎症有关.
端粒缩短是内动脉瘤中血管衰老的关键指标.

关键词:

在 NF-κBB 中.在mTOROR中使用mTOR.分子衰老的分子衰老氧化应激诱导的DNA损伤端粒的长度端粒的长度

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