在泌尿病原性大肠杆菌 (Escherichia coli) 中获得的卡巴酶基因的分布
Shervindokht Ahmadi1, Fatemeh Foroohi1, Maryam Shirzadian1
1Department of Microbiology, ShQ.C., Islamic Azad University, Shahr-E Qods, Iran.
Naunyn-Schmiedeberg's archives of pharmacology
|September 30, 2025
概括
该研究发现,在尿病原性大肠杆菌中,卡巴酶基因的高患病率,特别是blaSPM,有助于增加多药耐药性尿路感染. 需要紧急重新评估尿路感染治疗策略,以应对日益增长的耐药性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 遗传学 遗传学 是一个
背景情况:
- 抗菌耐药性 (ABR) 是一个日益增长的全球健康威胁,特别是在难以治疗的感染,如尿路感染 (UTI).
- 获得的碳烯酶基因 (ACG) 是抵抗的主要驱动因素,使治疗选择复杂化.
研究的目的:
- 确定尿病原性大肠杆菌 (UPEC) 中关键获得的碳酶基因 (ACG) 的流行率.
- 在UPEC菌株中建立ACG的基因分布概况.
- 为了将ACG患病率与抗菌耐药性模式相关联.
主要方法:
- 在2023年8月至2024年1月期间收集的105个UPEC阳性尿样的分析.
- 使用标准微生物学和生物化学方法确认分离物.
- 通过聚合酶链反应 (PCR) 和抗菌敏感性测试 (AST) 评估ACG,使用Kirby-Bauer光盘扩散方法.
主要成果:
- 最常见的ACG是blaSPM (82.86%),blaGIM (20.00%),以及blaVIM (16.19%).这些ACG中,最常见的是blaSPM (82.86%),blaGIM (20.00%),以及blaVIM (16.19%).
- 黑色SPM概况占主导地位 (35.24%) 并与高ABR率有很强的关联.
- 75.24%的菌株是多抗药性 (MDR),7.62%是广泛抗药性 (XDR) 和0.95%是抗药性 (PDR).
结论:
- 像blaSPM这样的ACG的高患病率和MDR,XDR和PDR菌株的增加需要紧急重新评估尿路感染治疗策略.
- 新的治疗方法对于控制和减少UPEC中进一步的耐药性发展至关重要.
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