在多性冠状动脉血管病症中,对子静脉和静脉内注射conbercept的效果进行比较
1The Second Clinical Medical College of Nanjing Medical University, Nanjing, 210003, China.
International ophthalmology
|September 30, 2025
概括
与静脉内注射相比,子视网膜内注射的conbercept显著改善了视力,并减少了多重性冠状血管病变 (PCV) 病变大小. 这种方法提供了更好的结果与更少的治疗.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 聚冠状血管病变 (PCV) 是新血管与年龄相关的黄斑变性的一种亚型.
- 目前对PCV的治疗包括抗血管内皮生长因子 (anti-VEGF) 治疗,通常通过静脉内注射进行.
研究的目的:
- 为了比较subretinal和intravitreal conbercept注射治疗PCV的临床疗效.
- 为了评估PCV患者的解剖和功能结果,接受不同的conbercept注射途径.
主要方法:
- 从2022年7月到2023年10月,对102名PCV患者进行了回顾性单中心研究.
- 患者接受了康伯塞普特注射,无论是通过内注射 (n=55) 还是通过内注射 (n=47).
- 评估包括多个时间点的最佳校正视敏度 (BCVA),OCT和ICGA在12个月内.
主要成果:
- 亚视网膜注射显示出显著更大的BCVA改善 (P<0.001) 和更明显的减少斑点视网膜厚度,亚膜胆道厚度和PED高度 (P<0.001).
- 亚基线组需要注射的次数较少 (P<0.001),并且实现了较高的聚回归率 (69.1%与42.6%,P=0.007).
- 在这两组中都没有报告明显的眼部或全身并发症.
结论:
- 与内注射相比,对PCV的子视网膜注射提供了更优越,更持久的解剖和功能结果.
- 这种方法减少了治疗负担,并增强了病变回归,表明其作为PCV有前途的替代疗法的潜力.
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