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Updated: Jan 16, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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在HOIP中出现的新型化合物异构基因突变导致自身炎症和免疫缺陷

Li Wang1,2, Jing Xiao3, Rui Gan1

  • 1Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.

Journal of clinical immunology
|September 30, 2025
PubMed
概括

在HOIP基因中的新突变通过破坏NF-κB激活和改变免疫细胞种群,导致严重的自身炎症和免疫缺陷. 这扩大了已知的HOIP相关疾病的范围.

关键词:
自动炎症是一种自发性炎症.一个堆,一个堆.卢巴克 (Lubac) 的一个地方.通过NF-κB路径.主要免疫缺陷是一个主要的免疫缺陷.这是一种I型干扰子.

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