在高影响期刊上的儿科后COVID状况研究的方法:系统性审查
Mary Rozelle1, Alyson Haslam1,2, Vinay Prasad1,3,4
1Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
JAMA network open
|September 30, 2025
概括
严格的研究设计对于定义儿科COVID后病情至关重要. 使用测试负控和标准化报告可以提高了解儿童和青少年长期健康影响的准确性.
科学领域:
- 儿科健康 儿科健康
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 在儿童中诊断COVID后的疾病是因为先前存在的健康问题而复杂的.
- 缺乏标准化的临床表型阻碍了定义和流行病学估计.
- 对儿科COVID后病情的高影响力研究很少,限制了政策信息的证据.
研究的目的:
- 审查和评估对儿科患者COVID后状况研究的方法.
- 评估大量引用的研究,以评估其可见性和潜在的政策信息.
- 描述用于检查儿童和青少年COVID后状况的方法.
主要方法:
- 在PubMed和Web of Science中搜索到2024年7月为止的COVID后病情的高度引用的儿科研究.
- 包括来自影响因子≥5.5的期刊的观察性或风险-收益研究.
- 使用乔安娜·布里格斯研究所和ROBINS-I工具评估偏差风险,根据对照组类型分类研究 (测试阴性与非测试阴性).
主要成果:
- 分析了426篇论文中的24篇;38%使用了检测负对照,63%没有.
- 在测试负的研究中,前性队列设计比非测试负的研究 (44%) 更常见 (33%).
- 不完整的人口统计报告 (性别,精神病史,并发症,BMI) 经常发生,样本大小小小.
结论:
- 强调需要严格的研究设计,以最大限度地减少儿科后COVID病情研究中的偏见和混.
- 强调测试负结果匹配对照对准确的风险因素评估的重要性.
- 建议标准化人口统计报告,以提高儿科COVID后病情研究的可比性和一致性.
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