在英国分离的新兴家禽病原体Enterococcus cecorum的表型和基因组分析
Finn O'Dea1, Amandine Dupuis1, Joseph Brown2
1Molecular Microbiology, School of Biosciences, University of Sheffield, Sheffield, UK.
Microbial genomics
|September 30, 2025
概括
在全球范围内,家禽感染Enterococcus cecorum的病例正在增加. 英国分离品显示出显著的抗生素耐药性,并与来自法国和美国的毒性菌株共享基因组特征,这表明跨大陆传播.
科学领域:
- 兽医微生物学 兽医微生物学
- 禽类的健康状况
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 自2002年以来,家禽感染Enterococcus cecorum的病例显著增加.
- 这种病原体会导致的脊椎感染,导致体排斥导致经济损失.
- 高抗微生物耐药性和毒性克隆系的出现有助于其传播.
研究的目的:
- 调查来自英国肉养殖场的Enterococcus cecorum分离物的基因组特征和抗菌耐药性.
- 为了比较英国的分离与来自其他国家的病原菌株.
主要方法:
- 对32种抗生素进行表型抗微生物敏感性测试 (MIC和ECOFF).
- 39个代表性的E. cecorum分离物的全基因组测序.
- 遗传学分析以确定克隆血统.
主要成果:
- 英国E. cecorum分离物对32种测试的抗生素中26种抗生素表现出耐药性.
- 临床分离物被丰富在一个特定的类.
- 这些菌株与来自法国和美国的病原菌株共享保存的细胞壁生物合成位点和移动遗传元素.
结论:
- 英国E. cecorum分离物具有与国际上发现的高度致病菌株相似的基因组特征.
- 这些发现支持了病毒性E. cecorum跨大陆传播的假设.
- 迫切需要采取战略来控制抗菌素耐药性E. cecorum在家禽中的传播.
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