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Updated: Jan 16, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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ER压力传感器PERK通过调节ER相关的降解来促进GVHD中的T细胞致病性

Qiao Cheng1, Hee-Jin Choi1, Yongxia Wu1,2

  • 1Department of Microbiology & Immunology and.

The Journal of clinical investigation
|September 30, 2025
PubMed
概括

细胞内膜网膜 (ER) 压力传感器PERK通过调节T细胞反应,显著影响移植对宿主疾病 (GVHD). 抑制PERK可以降低GVHD,同时保持移植与白血病 (GVL) 的活性,提供一种潜在的治疗策略.

关键词:
骨髓移植 骨髓移植免疫学 免疫学 免疫学炎症 炎症是一种炎症.

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