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Elif Aydin¹, Selahattin Celebi², Ozgur Celebi²

¹1Disinfection Sterilization and Antisepsis Department, Kütahya Health Sciences University, 43000, Kutahya, Turkey.

Acta microbiologica et immunologica Hungarica

|September 30, 2025

概括

全球占主导地位的大肠杆菌ST131克隆,特别是H30Rx亚克隆,在土耳其临床分离物中非常普遍,显示出广泛的抗菌素耐药性和毒性. 这突出了需要有针对性的监测的重大公共卫生风险.

科学领域:

微生物学微生物学
流行病学流行病学
遗传学是一个遗传学.

背景情况:

大肠杆菌 (E. coli) 是一种多功能细菌,会引起感染.
序列类型131 (ST131) 是一个具有全球意义的,多药耐药的大肠杆菌克隆.
ST131与严重的肠外和全身感染有关.

研究的目的:

对临床大肠杆菌分离物进行分子流行病学分析.
确定ST131及其H30Rx亚克隆的流行率.
评估抗菌素耐药性,毒性因子和大肠杆菌生物膜的形成.

主要方法:

分析了从2021年9月到2022年2月收集的160个临床大肠杆菌分离物.
传统和自动化细菌识别方法.
内部PCR测定用于分子特征,包括ST131和H30Rx检测.

主要成果:

发现了大肠杆菌ST131的高流行率 (69.38%).
ST131分离物经常携带毒性基因 (95.5%) 并形成生物膜 (81.99%).
在ST131中观察到广泛的多药性耐药性,主要由H30Rx亚克隆主导,ESBL产生的高率和诺基诺隆耐药性.

结论:

大肠杆菌ST131,特别是H30Rx亚克隆,在土耳其构成了严重的临床和公共卫生威胁.
这些发现强调需要加强对这种流行病血统的监测和控制策略.
对ST131的适应性特征的分子洞察力强调了它的多功能性和抵抗能力.

关键词:

美国大肠杆菌ST131 这就是ESBL.生物膜是一种生物膜.高危克隆高风险克隆整合一个整体.多种药物耐药性多种药物耐药性

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