化物对印度儿童认知发展的影响:系统性审查和元分析
Sowndarya Gunasekaran1, Soundarya Sakthivel2, Reshma Elizabeth Rajan1
1Department of Pediatric and Preventive Dentistry, Vinayaka Mission's Sankarachariyar Dental College, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, Tamil Nadu, India.
Journal of the Indian Society of Pedodontics and Preventive Dentistry
|September 30, 2025
概括
饮用水中的高化物与印度儿童的IQ得分较低有关. 这一系统性审查强调了脱化和对认知发展影响的进一步研究的需要.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 通过饮用水接触化物是全球公共卫生问题.
- 化物的潜在神经毒性影响,特别是对儿童,越来越令人担忧.
- 目前关于化物和印度儿童认知发展的证据有限且不一致.
研究的目的:
- 系统地审查和综合有关化物暴露与印度儿童认知发育之间的联系的现有证据.
- 量化化物暴露对该人口智商 (IQ) 成绩的影响.
- 为了确定最容易受到化物神经毒性影响的年龄组.
主要方法:
- 在多个科学数据库 (PubMed,Embase,Web of Science,Scopus,PsycINFO,Google Scholar) 进行了全面的文献搜索,截至2025年7月.
- 包括来自印度的观察性研究,重点关注0-18岁儿童及其饮用水中的化物暴露.
- 使用元分析技术分析了11项涉及6000多名参与者的研究.
主要成果:
- 接触化物度高于2.0ppm的饮用水的儿童的智商得分显著降低.
- 综合分析显示,暴露儿童的平均智商降低了6.5个 (95% CI: -7.3至 -5.7).
- 亚组分析表明,6-10岁的儿童特别容易受到这些认知缺陷的影响.
结论:
- 饮用水中的高化物暴露与印度儿童的认知能力受损有显著的关联.
- 调查结果强调,迫切需要区域性脱化水的战略,以减轻公共卫生风险.
- 建议进行进一步的纵向研究,以确定因果关系,并更好地了解暴露-反应关系.
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