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优化采集时间和重建参数的定量单光子发射计算机断层扫描/计算机断层扫描使用-123金属多基胺

Masakazu Tsujimoto¹, Masanori Watanabe², Kenta Nogami²

¹Department of Medical Equipment Engineering, Clinical Collaboration Unit, School of Medical Sciences, Fujita Health University, Toyoake, Japan.

|September 30, 2025

概括

准确的标准化吸收值 (SUV) 分析-123金属基 (123I-MIBG) 需要特定的成像参数. 对于123I-MIBG SUV测量来说,最优的结果是至少50秒/视图采集时间和特定的重建设置.

科学领域:

核医学是一种核医学.
医学成像物理医学成像物理

背景情况:

在SPECT成像中,准确的定量分析对于临床应用至关重要.
对-123金属基 (123I-MIBG) 的标准化吸收值 (SUV) 分析需要标准化的测量条件才能获得可靠的结果.

研究的目的:

为了确定最佳的测量条件,准确地分析123I-MIBG.SUV的最佳测量条件.
在123I-MIBG SPECT/CT.中调查图像收和量化之间的关系.

主要方法:

在JS-10和NEMA的身体幻影上进行了SPECT/CT成像,采集时间不同 (10-100s/view).
图像重建使用3D-OSEM与调整的子集代 (SI) 产品和高斯过器.
评估的参数包括剂量线性,恢复系数,散射比,变化系数,对比度和噪声比,以及SUV相对标准误差.

主要成果:

对123I-MIBG的最佳SUV测量得到了≥50s/view.的采集时间.
约120的SI乘法和10-12mm的高斯波器可以提高精度.
在最佳条件下,SUV的相对标准误差在5%以下.

结论:

对123I-MIBG进行精确的SUV测量需要至少50s/view的采集时间.
特定的图像重建参数 (SI产量~120,高斯过器10-12mm) 对于可靠的量化是必不可少的.
这些发现支持123I-MIBG SUV分析的临床应用.

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