大脑压力-流量关系健康低地人和高海拔本地人的方向灵敏度
Shahrzad Soleimani Dehnavi1,2, Jonathan D Smirl3,4,5,6,7,8,9, Marc-Antoine Roy1,2
1Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, Quebec, Canada.
概括
高海拔暴露不会改变低地人的大脑压力流动灵敏度. 这种现象,在血压升高与降低期间血流变化被缓冲,在适应过程中被保留.
科学领域:
- 生理学 生理学 生理学
- 高度医学 高度医学
- 脑血管调节 脑血管调节
背景情况:
- 大脑压力-流量关系的方向灵敏度,与降低的MAP相比,与上升的平均动脉压 (MAP) 相比,大脑血液速度的减弱变化,在高海拔地区尚不清楚.
- 低地人和喜尔巴等高海拔适应群体之间的这种敏感性的差异是未知的.
研究的目的:
- 为了调查大脑压力-流量关系方向敏感性是否在暴露在高海拔地区的低地人群中发生变化.
- 为了比较低地人与不同高度的谢尔帕人之间的这种敏感性.
主要方法:
- 连续记录MAP和中脑动脉的平均血液速度 (MCAv) 在重复的坐站 (RSS) 时在0.05Hz和0.10Hz.
- 测量是在海平面上进行的,在初次高空暴露后,在经过2周的适应后,在Sherpa.
- 在增加和减少期间计算MCAv与MAP变化的时间调整比率.
主要成果:
- 低地人始终在压力增加与压力下降期间显示较低的相对MCAv/MAP变化,无论高度如何.
- 部分适应的低地人和Sherpa在0.05 Hz RSS时表现出这种方向灵敏度,但不是在0.10 Hz RSS时.
- 与海平相比,对高海拔地区的急性和部分适应并没有改变低地人的大脑压力-流动方向灵敏度.
结论:
- 大脑压力-流量关系的方向敏感性在低地人中在急性高空暴露和部分适应期间保持.
- 在Sherpa观察到的类似hysteresis的模式与部分适应低地人的模式相似.
- 这种保留的灵敏性可能会保护大脑微血管系统免受缺氧引起的血压升高的影响,尽管在较高频率的Sherpa中它不存在.
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