血清桑丁氧化还原酶和氧化应激与膀癌有关:约旦的一项病例对照研究
Journal of applied biomedicine
|September 30, 2025
概括
血清中高氨酸氧化酶 (XO) 水平和特定的氨酸氧化减少酶 (XOR) 基因变异与增加膀癌 (BC) 风险有关. 这些发现表明,XO和XOR可能是BC诊断和治疗的潜在生物标志物.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 氧化应激是膀癌 (BC) 的一个主要因素,与吸烟和遗传易感性有关.
- 丁氧化降解酶 (XOR) 存在于丁脱酶 (XDH) 和丁氧化酶 (XO) 形式;XO可能通过致癌物激活和自由基生成促进瘤发生.
研究的目的:
- 调查血清XO水平和与BC.的XOR遗传多态性之间的关联.
- 在BC患者中评估氧化应激生物标志物.
主要方法:
- 一项涉及109名BC患者和109名对照者的病例控制研究.
- 测量了血清XO,8-hydroxy-2'-deoxyguanosine (8-OhdG),铁酸反应性物质 (TBARS) 和蛋白质碳基 (PC) 的含量.
- 使用四级原始ARMS-PCR分析了XOR单核酸多态 (SNPs).
主要成果:
- 与对照组相比,BC患者的血清XO水平显著提高 (p < 0.0006).
- 在BC患者中观察到氧化应激生物标志物 (8-OHdG,PC,TBARS) 的水平升高.
- 特定的XOR类型 (TGTCA,TGTA,TGA,GTA) 在BC患者中更频繁,与BC风险增加相关.
结论:
- 较高的XO和氧化应激标志物与BC有关,表明其在病变发生过程中的作用.
- 氧化氧和氧化应激标志物可以作为BC的潜在诊断或治疗点.
- 特定的XOR单元类型可能被用作BC.的生物标志物.
相关概念视频
Electron Transport Chain: Complex I and II
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...


