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Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
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植物素通过调节肠道微生物群和炎症反应来缓解DSS诱导的大肠炎
Ruping Shan1, Kexin Wang2, Qiujie Chen1
1Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun 130062, Jilin Province, China.
International immunopharmacology
|September 30, 2025
概括
植物素 (PS) 在实验性大肠炎中显著减少炎症并改善肠道屏障功能. 这种天然化合物还积极调节肠道微生物群,为炎症性肠病 (IBD) 干预提供了潜在的新策略.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 全球炎症性肠病 (IBD) 患病率正在上升,这给公共卫生带来了重大挑战.
- 目前的IBD疗法有局限性和不良影响.
- 菲索斯芬戈辛 (PS) 是一种脂代谢物,具有抗炎性质.
研究的目的:
- 在小鼠中研究植物素 (PS) 对硫酸 (DSS) 诱导的大肠炎的保护作用.
- 阐明PS在减轻实验性结肠炎的潜在机制.
主要方法:
- 在DSS诱导的大肠炎的小鼠模型中,口服PS.
- 评估结肠损伤,炎症性细胞因子水平 (TNF-α,IL-1β) 和肠道屏障标记物 (mucin-2,紧结).
- 分析NF-κB信号传递,氧化应激,PPARγ表达,肠道微生物群组成和短链脂肪酸概况. 进行了便微生物群移植 (FMT).
主要成果:
- PS显著缓解了DSS诱导的结肠损伤,并减少了促炎细胞因子.
- PS改善了肠道屏障功能,抑制了NF-κB激活,减少了氧化应激,并增强了PPARγ表达.
- PS减轻了肠道失调,增加了有益细菌 (Bacteroidota) 和增加了短链脂肪酸 (丁酸盐,酸盐). 接受PS治疗的捐赠者的FMT给予了保护.
结论:
- 植物素 (PS) 在小鼠实验中显示出对实验性大肠炎的显著保护作用.
- PS通过改善肠道屏障功能,减少炎症,调节肠道微生物群的组成和功能来起作用.
- PS代表了IBD的一个有希望的治疗候选者,可能是通过针对微生物群的干预措施.
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