新兴和重新出现的病毒感染及其眼部表现:关注眼部新血管化
Dan Li1, Qing Ye1, Jianhao Bai2
1Department of Ophthalmology, Suzhou Kowloon Hospital Shanghai Jiao Tong University School of Medicine, Suzhou, 215028, China.
Molecular aspects of medicine
|September 30, 2025
概括
像SARS-CoV-2和HIV这样的新兴病毒可能会导致眼球新血管化 (ONV),导致视力丧失. 本综述探讨了病毒机制和治疗策略,以管理这些危及视力的眼睛疾病.
科学领域:
- 眼科医生 眼科 眼科
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 新兴的病毒感染构成全球健康风险,经常导致系统性并发症.
- 病毒性疾病的眼部表现越来越被认为是视觉发病的原因.
- 眼部新血管化 (ONV) 是与病毒感染有关的重大并发症.
研究的目的:
- 审查主要新兴和重新出现的病毒病原体的眼部序列.
- 突出病毒在眼睛新血管化 (ONV) 中的作用.
- 讨论病毒相关ONV的机制,诊断和治疗方法.
主要方法:
- 对案例报告和实验模型的文献综述.
- 对导致ONV的病毒学和免疫学机制的分析.
- 专注于病毒,如SARS-CoV-2,艾滋病病毒,西尼罗河病毒 (WNV) 和登革热病毒 (DENV).
主要成果:
- 病毒可以通过直接的细胞病变影响,炎症和血管生成因子的失调来诱导ONV.
- 机制涉及诸如血管内皮生长因子 (VEGF) 和缺氧诱导途径等因素.
- ONV可以影响眼睛的各种部位,包括角膜,虹膜,视网膜和眼膜.
结论:
- 了解病毒诱导的ONV机制对于预防视力丧失至关重要.
- 需要有针对性的治疗策略来解决病毒感染和眼神血管通路之间的相互作用.
- 进一步的研究对于有效管理与病毒相关的眼部并发症至关重要.
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