在MASH治疗中通过架跳跃发现了基于英达的新型强效FXR激活剂

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Da-Yu Shi1, Xin-Wei Shi1, Hang Shi2

  • 1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.

European journal of medicinal chemistry
|September 30, 2025
PubMed
概括

研究人员开发了一种新型化合物E2,该化合物向法尔内索伊德X受体 (FXR),用于治疗代谢相关肝炎 (MASH). 在临床前模型中,E2表现出强烈的活性和改善肝脏健康,显示出MASH治疗的前景.

关键词:
在 FXR 和 FXR 之间.伊达尔的脚手架是一个脚手架.马什 (MASH) 是一个非常重要的产品.脚手架跳跳策略是一个策略.结构与活动之间的关系.

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