调查双和糖尿病之间的关联:从流行病学和生物信息学证据
Li Jie1, Zhao Yupeng2, Liu Huan1
1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, PR China.
双F (BPF) 暴露与美国成年人糖尿病风险增加有关. 分子分析显示,BPF可能会破坏胰岛素和脂质代谢,凸显了对BPA替代品的担忧.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 双A (BPA) 在塑料中广泛使用,并与各种疾病有关.
- 双F (BPF) 和双S (BPS) 是常见的BPA替代品,但它们的安全性受到争议,特别是在糖尿病风险方面.
研究的目的:
- 评估双暴露与美国成年人糖尿病患病率之间的关联.
- 通过网络毒理学和分子对接,研究BPF诱导的糖尿病的分子机制.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据.
- 网络毒理学,分子对接和调解分析,以探索分子途径.
- 基于年龄的分层分析,以检查代谢异质性.
主要成果:
- 在BPF暴露和糖尿病患病率之间发现了显著的关联 (OR = 1.04,P = 0.032).
- 观察到年龄相关的关联:50岁以下的线性,老年人的非线性.
- BPF与蛋白质 (FN1,GAPDH,TP53) 相互作用,可能会损害胰岛素耐药性和脂质代谢 (结合 afinities -5.1 到 -7.0 kcal/mol).
- 甘油三可能掩盖了BPF对老年糖尿病的直接影响.
结论:
- 暴露于BPF与美国成年人糖尿病患病率增加有关.
- 分子机制涉及通过蛋白质相互作用损害胰岛素和脂质代谢.
- 调查结果强调需要对BPA替代品如BPF进行严格的安全评估.
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