全球流行病学和基因组观点对抗万科胺素耐药Enterococcus faecium:在一个卫生框架内,抗菌素耐药性和传播风险的增加
Xiangyu Yu1, Zhaorong Yu2, Liang Huang1
1School of Information and Artificial Intelligence, Anhui Agricultural University, Hefei, 230036, China; Anhui Province Engineering Laboratory for Animal Food Quality and Bio-safety, Anhui Agricultural University, Hefei, 230036, China.
抗万科素的Enterococcus faecium (VREfm) 菌株正在全球范围内在人类,动物和环境中传播. 抗生素耐药性基因的增加,需要加强监测和感染控制在一个健康的方法.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 耐万科素的Enterococcus faecium (VREfm) 是一种多药耐药的细菌,导致难以治疗的感染,并对公共卫生构成威胁.
- 在人类,动物和各种环境中发现了VREfm,这表明其传播范围广泛.
研究的目的:
- 分析VREfm的全球多样性,传播模式和抗生素耐药性概况.
- 研究抗生素耐药性基因 (ARG) 的进化及其与移动遗传元素的相关性.
主要方法:
- 分析了来自不同来源和49个国家的1632个vanA或vanB阳性VREfm分离物.
- 多部位序列类型 (MLST),遗传学分析,分裂k-mer和核心基因组SNP分析.
- 生物信息学用于ARG识别和与移动遗传元素的相关性,使用可解释的人工智能.
主要成果:
- 确定了127种序列类型 (ST),其中ST117和ST80是最常见的;在美国注意到ST多样性更高.
- 基因组聚类揭示了跨物种,跨境和医院传播.
- 在过去的30年里,观察到每个隔离体的ARG增加了42%,人类隔离体和来自低收入国家的隔离体显示出更高的ARG负担.
结论:
- VREfm表现出多方向扩散和不断变化的阻力模式,强调需要持续监测.
- 移动遗传元素,特别是等离子体,与ARG增加密切相关.
- 强调"一个健康"框架对VREfm监测和控制的重要性,以及加强流行病学警和感染控制实践.
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