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创伤性脑损伤中的花素-阿曼塔丁试验:一项前性随机研究

Dina Salah Eldin Mahmoud Badre¹, Marwa Ahmed Khairy Elbeialy¹, Mai Fathy²

¹Department of Anesthesia, ICU and Pain, Ain Shams University, Cairo, Egypt.

Journal of neurotrauma

|September 30, 2025

概括

阿曼塔丁单独或与胆一起,在中度创伤性脑损伤 (TBI) 患者中改善了意识和认知功能. 这些治疗方法还减少了机械通风和住院时间,相比单独使用西提科林.

科学领域:

神经科学是一个神经科学.
临床神经学临床神经学
药理学药理学是指药理学的学科.

背景情况:

创伤性脑损伤 (TBI) 是一个重大的全球健康挑战.
阿曼塔丁和胆已经证明了促进TBI后神经恢复的潜力.

研究的目的:

为了比较阿曼塔丁,花素及其组合对中度TBI早期阶段的兴奋和行为结果的影响.

主要方法:

这是一项随机对照试验,涉及45名中度TBI患者,分为三组:胆,阿曼塔丁和组合治疗.
患者接受了30天的治疗,评估包括格拉斯哥昏迷量表 (GCS),残疾评级量表 (DRS) 和微型精神状态 (MMS) 在不同的时间点.
测量结果包括机械通风的持续时间,ICU和住院时间,以及死亡率.

主要成果:

阿曼塔丁和组合疗法组在4,7和30天显示出明显更高的GCS得分,与仅服用胆的组相比.
阿曼塔丁和组合组在第4天和第7天表现出明显较低的DRS分数.
仅服用花素的组在评估日内显示出显著较低的MMS得分.
机械通风的持续时间,ICU和住院时间在仅服用醇的组中显着更长.

结论:

阿曼塔丁,无论是单独使用还是与胆结合使用,都会对中度TBI患者的意识恢复和认知行为产生积极影响.
基于阿曼塔丁的治疗与机械通风的持续时间缩短以及ICU和住院时间缩短有关.

关键词:

阿曼塔丁 (Amantadine) 是一种阿曼塔丁 (Amantadine) 的一种药物.这种药物是Citicoline.创伤性脑损伤是一种创伤性脑损伤

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Traumatic Brain Injury l: Introduction

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...