对动脉血液动力学进行计算流体结构相互作用分析,用于评估心血管风险
Hedyeh Mahjoub1, Kamran Hassani1,2, Ali Sheikhani1
1Department of Biomedical Engineering, SR.C, Islamic Azad University, Tehran, Iran.
Computer methods in biomechanics and biomedical engineering
|September 30, 2025
概括
先进的计算机模型模拟主动脉中的液体结构相互作用 (FSI) 改善了心血管疾病风险预测. 双向合FSI模型提供比单向模型更准确的墙壁应力估计.
科学领域:
- 生物医学工程 生物医学工程
- 计算流体动力学的流体动力学.
- 心血管力学心血管力学
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 改善心血管疾病的诊断和治疗策略需要先进的计算建模.
- 了解动脉壁在生理和病理条件下的行为至关重要.
研究的目的:
- 通过一种新的流体结构相互作用 (FSI) 模型,研究动脉壁的血液动力学和结构性行为.
- 为了比较单向和双向合FSI模型,以评估它们对心血管参数的影响.
- 评估复杂的FSI建模对个性化心血管风险预测的潜力.
主要方法:
- 使用COMSOL多物理开发了大动脉及其分支的三维 (3D) 计算模型.
- 模拟动脉壁作为超弹性材料,并假设牛顿式的血液流动.
- 实现并比较单向和双向流体结构相互作用合.
主要成果:
- 双向合FSI模型显示,血液流动和动脉力学之间的双向相互作用更准确,与单向合相比,增加了30%的墙壁应力估计.
- 模拟显示,在高粘度 (0.1Pa·s) 下,近道主动脉的峰值速度约为0.13m/s,下游下降.
- 静脉压从大动脉入口下游下降,在高血压下 (160 mmHg) 观察到4.10微米的最大位移,与易患疾病地区的高机械应力相关.
结论:
- 复杂的流体结构相互作用 (FSI) 建模,特别是双向合,显著提高了心血管模拟的准确性.
- 开发的FSI模型为各种生理和病理条件下的大动脉的血液动力学和结构性行为提供了宝贵的见解.
- 这种先进的建模方法在改善个性化风险预测和心血管疾病管理方面具有巨大的潜力.
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