在现役女性中使用避孕药和骨折风险 - - 一项病例对照研究
Brenna Ryan1, Anne Brezovec2, Saixia Ying3
1Tripler Army Medical Center.
Contraception
|September 30, 2025
概括
这项研究发现,使用荷尔蒙避孕药,包括口服避孕药 (OC),贴片和阴道环,一般不会增加军事压力骨折的风险. 建议对长期使用进行进一步调查.
科学领域:
- 军事医学 军事医学
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
背景情况:
- 军事准备受到压力骨折的影响.
- 激素避孕药的使用在活跃的女性中很常见.
- 在部署期间持续使用避孕药可能会带来骨折风险.
研究的目的:
- 为了确定是否使用荷尔蒙避孕药与军事压力骨折有关.
- 评估与不同类型的荷尔蒙避孕药有关的压力骨折风险.
- 为活跃女性提供信息,考虑处方.
主要方法:
- 一个用发病密度抽样进行的病例控制研究.
- 匹配病例 (压力骨折) 最多有四个对人口统计和服务历史的控制.
- 分析子宫内器械 (IUD),植入物和注射剂分别;口服避孕药 (OC),贴片和阴道环组合.
- 计算调整后的发病率比率 (IRR) 和95%的置信区间 (CI).
主要成果:
- 病例更有可能被招募,缺乏维生素D,肥胖,并且有骨病史.
- 在调整之前,没有激素避孕药与骨折风险相关.
- 在调整肥胖和等级后,联合OC/贴片/阴道环在使用2-3年后显示出与压力骨折的统计学上显著的关联 (IRR2.17,95%CI1.10-4.28).
结论:
- 最近使用荷尔蒙避孕药与增加压力骨折风险之间的联系有限或不存在.
- 与联合OC/贴片/阴道环的潜在关联需要进一步调查.
- 荷尔蒙避孕药与这种队列中压力骨折风险的增加无关,支持当前有关骨健康的知识和对活跃女性的处方.
更多相关视频
06:58Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
Published on: August 17, 2017
10.3K
04:19Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
Published on: November 8, 2024
1.1K
相关概念视频
01:27Fractures: Bone Repair
4.9K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
4.9K
01:20Study Designs in Epidemiology
840
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
840
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:22Birth Control Methods
5.8K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.8K