奥利塞里丁和苏芬坦尼尔在腹部手术中对术后恶心和吐的影响 (EOSPONVAS):多中心,双臂,随机对照试验的协议
Jie Luo1, Lizhen Wang1, Zhongping Jie2
1Department of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China.
BMJ open
|September 30, 2025
概括
这项研究研究了奥利塞里丁用于减少术后恶心和吐 (PONV) 以及改善腹部手术后的康复. 它在一个随机试验中将奥利塞里丁与苏芬坦尼尔进行了比较.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 术后恢复 术后恢复
背景情况:
- 奥利塞里丁是一种新的μ-阿片类受体选择性激动剂.
- 它提供了疼痛缓解,潜在的副作用比传统阿片类药物少.
- 对于其在腹部手术中使用的证据有限.
研究的目的:
- 评估奥利塞里丁在减轻腹部手术患者手术后恶心和吐 (PONV) 的疗效.
- 与sufentanil相比,评估oliceridine对患者康复和安全的影响.
主要方法:
- 未来的,多中心的,双臂的,随机的试验.
- 494名参与者接受了可选的大型腹部手术,随机分配给奥利塞里丁或苏芬坦尼尔用于患者控制的止痛疗法 (PCIA).
- 主要结局:PONV发生率在48小时内;次要结局:疼痛得分,恢复指标和安全.
主要成果:
- 主要结果数据尚未提供,因为研究仍在进行中.
- 二次结果数据收集包括恶心严重程度,吐频率,疼痛评分 (NRS),恢复质量 (QoR-15) 和PCIA使用情况.
- 安全结果监测阿片类药物相关的不良影响和外科手术后并发症.
结论:
- 这项研究将提供关于奥利塞里丁在腹部手术中的有效性和安全性的关键数据.
- 这些发现可能会为临床实践提供有关术后疼痛管理阿片类药物选择的信息.
- 在这种患者群体中,奥利塞里丁可以为PONV和康复提供更好的安全性.
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