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MINMON-J:一项混合实施试点研究,评估在监狱环境中低障碍型肝炎C治疗模式

Justin Berk¹, Emily S Fu², Matthew Murphy³

¹Brown University Warren Alpert Medical School, Providence, Rhode Island, USA justin_berk@brown.edu.

|September 30, 2025

概括

这项研究适应了低障碍C型肝炎病毒 (HCV) 治疗模式,用于监禁人员. MINMON-J试验表明,这种方法在监狱中治疗HCV是可行的和可以接受的.

科学领域:

传染性疾病传染性疾病
实施科学实施科学
惩戒卫生卫生机构

背景情况:

肝炎C病毒 (HCV) 是美国传染病死亡的主要原因,不成比例地影响监禁人口.
直接作用抗病毒药物提供高治愈率,但监狱中的治疗机会受到系统性障碍的限制.
在MINMON-J研究中,在校正环境中适应了对HCV的最小监测治疗模型.

研究的目的:

在监狱环境中适应和评估C型肝炎病毒 (HCV) 修改后的最小监测 (MINMON) 治疗模式.
为应对对司法涉及个人的可扩展,低障碍治疗选择的迫切需要.
评估这种适应模型的可行性,可接受性和遵守性.

主要方法:

罗德岛州惩戒部门的一项单臂混合有效性实施试点研究.
40名以前没有接受过治疗的,非肝硬化症的,被监禁的个人接受了12周的索福斯布维尔/韦尔帕塔斯维尔,并进行了最小的监测.
使用行政数据,调查和定性访谈进行混合方法评估,以RE-AIM/PRISM框架为指导.

主要成果:

主要结果集中在可行性,可接受性和对MINMON-J干预措施的遵守上.
数据收集包括行政记录,验证调查 (AIM,FIM,BARs) 和定性访谈.
如果参与者在治疗完成之前被释放,社区卫生工作者会提供释放后的支持.

结论:

MINMON-J研究协议旨在评估监狱中HCV治疗的新方法.
这些发现将有助于在惩戒系统中扩展低障碍HCV治疗模式.
成功实施可以显著改善司法参与人口的HCV结果.

关键词:

临床试验临床试验可行性研究可行性研究卫生服务卫生服务卫生服务公共卫生公共卫生患者导航患者导航

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