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Updated: Jan 16, 2026

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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
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在儿科瘤学中对BSREM重建的临床评估使用[18F]FDG PET/CT
Nicholas A Shkumat1,2, Reza Vali3,2, Amer Shammas3,2
1Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Ontario, Canada; and nicholas.shkumat@sickkids.ca.
Journal of nuclear medicine technology
|September 30, 2025
概括
具有500或更高的规范化参数 (β) 的区块顺序规范期望最大化 (BSREM) 能够在儿童癌症患者中实现诊断质量[FDG PET/CT,即使计数密度降低. 这允许更低的注射活动和更短的扫描时间.
科学领域:
- 核医学是一种核医学.
- 医学成像物理 医学成像物理
背景情况:
- pozitron发射断层扫描 (PET) 的技术进步,包括光倍增器和块序规则化预期最大化 (BSREM),需要对最佳儿科成像参数进行重新评估.
- 评估在儿科瘤患者中减少注射活动或获得持续时间的可行性对于剂量减少和改善患者体验至关重要.
研究的目的:
- 为了评估BSREM重建和数字[18F]FDG PET/CT中不同计数密度 (CD) 的性能,用于儿科癌症成像.
- 为了确定是否可以减少注射活动或扫描时间,同时保持诊断图像质量.
主要方法:
- 对20名接受PET/CT治疗的儿科患者500个独特重建的回顾性分析.
- 用光倍增器PET/CT系统获得的成像;使用有序子集期望最大化 (OSEM) 和具有不同规范化强度 (β) 的BSREM进行的重建.
- 医生对技术质量和诊断满意度的评分,以及与标准护理 (SOC) 相比的定量SUV测量.
主要成果:
- 与OSEM相比,BSREM重建与β ≥500显著改善了所有CD的整体得分.
- 噪声性能随着更高的规范化而改善;空间分辨率在β = 350时是最佳的.
- 诊断图像质量在25%CD使用BSREM与β≥500实现;SUVmax与SOC的差异为≤15% (≤10%与最佳参数).
结论:
- 全身[18F]FDG 儿科患者的PET/CT诊断为BSREM (β ≥ 500),即使CD减少.
- 定制的采集和重建参数可以实现定量准确性 (SUVmax差异≤10%),同时减少辐射剂量和成像时间.
- 这种方法优化了儿科患者的护理,使注射活性降低,扫描持续时间缩短.
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