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短链脂肪酸及其肠道微生物通路在不和的单胞胎双胞胎中区分了类风湿性关节炎

Rebecca B Blank¹, Kevin Bu², Xinyuan Zhang³

¹Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA.

Annals of the rheumatic diseases

|September 30, 2025

概括

患有类风湿性关节炎 (RA) 的同卵双胞胎在肠道微生物群中显示了短链脂肪酸 (SCFA) 和SCFA产生细菌的水平降低. 这些发现表明RA发展和辅助疗法的潜在生物标志物.

科学领域:

类风湿病学类风湿病学
微生物组研究的研究.
多种组合的多种组合.

背景情况:

风湿性关节炎 (RA) 的发病包括像HLA-DRB1等位基因的遗传因素,但单胞胎 (MZ) 双胞胎的低一致性表明了关键的非遗传影响.
非遗传因素,特别是微生物和宿主生物标志物在RA发展中的具体贡献仍然不充分描述.

研究的目的:

通过使用多组学方法来表征主体和微生物生物标志物,区分RA-discordant MZ双胞胎.
研究肠道微生物及其代谢物在RA病变发生过程中的作用.

主要方法:

研究了8对RA异调的MZ双胞胎 (美国队列) 并在英国双胞胎注册表 (TwinsUK) 中验证了研究结果.
通过中枪元基因组测序评估肠道微生物组.
使用GC-MS测量了血和便中的自身抗体,细胞因子,血蛋白和短链脂肪酸 (SCFA).

主要成果:

在RA异调双胞胎之间,没有观察到整体微生物群多样性或组成的显著差异.
受影响的RA双胞胎表现出显着较低的SCFA产生细菌水平 (例如,Blautia faecis) 和减少便中的丁酸盐和酸盐度.
验证队列 (TwinsUK) 显示,SCFA生产的种群 (Gemmiger formicilis,Faecalicatena fissicatena) 和细菌SCFA代谢途径的减少类似.

结论:

多组学生物标志物可以区分MZ双胞胎对RA不一致.
减少便丁酸盐,酸和SCFA产生细菌与受影响双胞胎的RA有关.
结果表明,在RA诊断和辅助疗法开发中,多组学方法的潜力存在,等待在更大的队列中验证.

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