由于肠道病毒A71引起的慢性脑膜大脑炎复杂化了rituximab治疗
A David1, M Claudé2, G Martin de Frémont3
1Department of Neurology, Saint-Denis Hospital Center, Saint-Denis, France.
Revue neurologique
|September 30, 2025
概括
利图西马布治疗可以导致严重的肠道病毒感染,如慢性脑膜炎. 用静脉注射免疫球蛋白 (IVIg) 和素迅速治疗导致一个患有非霍奇金淋巴瘤的患者显著恢复.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 瘤免疫学 瘤免疫学
背景情况:
- 利图西马布 (抗CD20疗法) 广泛用于自身免疫和血液学疾病.
- 这种疗法可能会导致持续的免疫功能受损,增加感染风险.
- 慢性肠道病毒脑膜炎是一种罕见但严重的并发症.
研究的目的:
- 在接受Rituximab维持治疗的患者中报告慢性肠道病毒A71 (EV A71) 脑膜炎病例.
- 审查有关肠道病毒脑膜炎并发症的文献复杂化rituximab治疗.
- 评估静脉注射免疫球蛋白 (IVIg) 和fluoxetine在治疗这种疾病中的有效性.
主要方法:
- 一个38岁的男性患有地幔细胞淋巴瘤,接受了Rituximab治疗的病例报告.
- 对与rituximab相关的肠道病毒脑膜炎病例的文献综述.
- 为患者开始每月IVIg和fluoxetine治疗.
主要成果:
- 患者出现了神经系统的恶化,诊断为慢性EV A71脑膜炎.
- 用IVIg和fluoxetine治疗在六个月内导致了显著的临床改善.
- 文献综述表明,高剂量IVIg往往可以改善结果;素在体外显示抗病毒活性.
结论:
- 在有脑发作症状的Rituximab治疗患者中,必须考虑肠道病毒感染.
- 用高剂量的IVIg恢复幽默免疫力可能会改善患者的治疗结果.
- 这一案例突出了对Rituximab治疗的罕见但严重并发症的潜在治疗策略.
关键词:
这是一个反CD2020的反CD20.复杂化 复杂化 复杂化 复杂化痴呆症是一种痴呆症.进入病毒性脑膜大脑炎.肠道病毒A71 A71这种情况是Hypogammaglobulinemia.非霍奇金淋巴瘤是一种非霍奇金淋巴瘤.里图西马布 (Rituximab) 是一种药物.更多相关视频
10:50Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
8.2K
05:55Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
Published on: December 1, 2023
1.3K
相关概念视频
01:23Rheumatic Heart Disease I: Introduction
447
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
447
01:14Myocarditis III: Medical Management
175
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
175