阿尔茨海默病研究中心设置中的认知变化指数:对认知衰退的自我和告知者评分
Yousaf Abughofah1,2, Shannon L Risacher1,2, Frederick W Unverzagt2,3
1Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|September 30, 2025
概括
认知变化指数 (CCI) 有效地选轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 痴呆症. 自我报告和信息报告都在区分认知不受损的个体和认知受损的个体方面表现出很高的准确性.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 心理测量 心理测量 心理测量
背景情况:
- 认知变化指数 (CCI) 是一个简短的问卷,通过自我和信息人报告来评估认知功能.
- 区分认知正常 (CU) 个体与轻度认知障碍 (MCI) 或阿尔茨海默病 (AD) 痴呆症患者之间的区别对于及时干预至关重要.
研究的目的:
- 评估CCI在区分CU老年人和患有MCI或AD痴呆症的个人的有效性.
- 评估CCI的自我和告密者版本的诊断准确性.
主要方法:
- 来自印第安纳州阿尔茨海默氏病研究中心 (IADRC) 和他们的研究伙伴的485名参与者完成了20项自我和信息人CCI.
- 采用接收机运行特征 (ROC) 曲线分析来确定CCI的歧视力.
主要成果:
- 在两种CCI版本中都实现了曲线下的高面积 (AUC) 值.
- 提供信息的CCI表现优异,AUC为0.914 (95%CI:0.886-0.942),而自我报告的CCI的AUC为0.803 (95%CI:0.761-0.844).
结论:
- 在多模式评估框架内,CCI是MCI和痴呆症的宝贵查工具.
- 这些发现支持CCI在早期阿尔茨海默病 (AD) 查和诊断方面的潜在作用.
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