在R和Python中使用最佳实践和工具,用于统计处理和可视化脂组学和代谢学数据
Jakub Idkowiak1,2, Jonas Dehairs2, Jana Schwarzerová3,4,5
1Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czechia.
Nature communications
|September 30, 2025
概括
本综述汇编了免费访问的R和Python工具,用于探索和可视化复杂的脂组学和代谢学数据. 它指导初学者使用这些解决方案进行强大的,可复制的OMIC数据分析和准备出版的图形.
科学领域:
- 计算生物学 计算生物学
- 生物信息学是一种生物信息学.
- 数据科学数据科学数据科学
背景情况:
- 脂组学和代谢学产生大型数据集,需要先进的数据探索技能.
- 识别统计学上显著的趋势和生物差异需要专门的可视化技术.
- 现有的量身定制的方法是实验室特定的,突出了对可访问,标准化的工具的需求.
研究的目的:
- 审查和编译可自由访问的R和Python工具,用于探索性数据分析和对omics数据的可视化.
- 引导研究人员,特别是初学者,培养分析和可视化复杂生物数据集的技能.
- 促进R和Python的使用,以便在欧米学研究中进行可靠和可重复的化学测量分析.
主要方法:
- 编译现有的,免费可用的R和Python库,用于数据分析和可视化.
- 包括描述性统计,假设测试和各种情节类型 (例如盒子情节,火山情节,热图) 的方法.
- 关于无监督和监督的维度减小技术和层次分类 (dendrograms) 的指导.
主要成果:
- 介绍了一个精心策划的R和Python工具选择,用于关键的OMIC数据探索任务.
- 该审查包括编制描述性统计数据,注释框图,假设测试,火山图,脂质图和脂肪酸链图.
- 为全面的数据可视化提供了无监督和监督的维度减小,树状图和热图的指导.
结论:
- 自由访问的R和Python工具为分析和可视化omics数据提供了强大的解决方案.
- 这份指南使研究人员能够进行可重复的化学测量分析,并生成准备出版的图形.
- 相关的GitBook存储库提供了这些数据分析技术的实际应用的逐步说明.
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