在产后期间,西会对母亲和后代产生长期的不良影响
Cassandra J Hatzipantelis1,2, Min Liu1,3, Adam Love4
1Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, USA, CA.
Nature communications
|September 30, 2025
概括
在小鼠中,psilocybin没有缓解母亲的压力行为,并且在母亲中增加了焦虑. 通过母乳养暴露于psilocybin的后代后来表现出减少的快乐,这表明在分娩后期使用迷幻药的潜在风险.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- псилоцибин在治疗心理健康状况方面表现有前途.
- 产前情绪障碍涉及母亲的脱节和焦虑.
- 西对产后心理健康的影响尚不清楚.
研究的目的:
- 在产后小鼠模型中研究psilocybin的疗效和安全性.
- 检查psilocybin对母亲行为和压力的影响.
- 评估对后代发育和行为的影响.
主要方法:
- 用一个社会压力模型在的小鼠 (母亲).
- 在产后期间向母体给予psilocybin.
- 评估了母亲的行为,焦虑和成年后代的无情感.
主要成果:
- 西并没有减少压力诱导的孕产妇戒断或行为.
- 接受了松素治疗的母体在治疗后表现出增加的焦虑,而不管压力如何.
- 在哺乳期暴露于母亲psilocybin的后代显示成年人无.
- 在女性中观察到血清素受体转录和5-HT2A反应的减少.
结论:
- 在产后情绪障碍方面,西可能没有效果.
- 母亲和后代可能特别容易受到产后西宾的伤害.
- 需要对产后期的迷幻安全性进行进一步的研究.
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