Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.1K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.1K
Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

4.1K
A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
4.1K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

290
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
290
Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

Nonlinear Pharmacokinetics: Causes of Nonlinearity

710
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
710
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

292
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
292
Linear Approximation in Time Domain01:21

Linear Approximation in Time Domain

345
Nonlinear systems often require sophisticated approaches for accurate modeling and analysis, with state-space representation being particularly effective. This method is especially useful for systems where variables and parameters vary with time or operating conditions, such as in a simple pendulum or a translational mechanical system with nonlinear springs.
For a simple pendulum with a mass evenly distributed along its length and the center of mass located at half the pendulum's length,...
345

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Phenotype Matching: RF Sensor-Based Indoor Subject Identification with Wearable Sensor Assistance.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Revisiting the relationship between pulse transit time and arterial stiffness.

Pflugers Archiv : European journal of physiology·2025
Same author

Non-contact imaging of the neck for monitoring cardiopulmonary clinic patients.

Biomedical optics express·2025
Same author

Model-Based Characterization of the Metabolism of Recombinant Adeno-Associated Virus (rAAV) Production via Human Embryonic Kidney (HEK293) Cells.

Bioengineering (Basel, Switzerland)·2025
Same author

Non-contact Heart Rate and Respiratory Rate Estimation from Videos of the Neck.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Novel metrics for tracking blood pressure changes incontinuous cuffless blood pressure estimations.

Scientific reports·2024
Same journal

Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.

Scientific reports·2026
Same journal

Microbial contamination of donor corneas and post-keratoplasty endophthalmitis: a comparison between Japanese and U.S. eye banks using cold storage.

Scientific reports·2026
Same journal

Prevalence and contributing factors of virological non-suppression among adult patients on first-line antiretroviral therapy in tertiary hospitals in Ethiopia.

Scientific reports·2026
Same journal

An in vitro comparison of color stability between alkasite and different restorative materials in various staining solutions.

Scientific reports·2026
Same journal

Toward accessible mRNA LNP formulation: systematic evaluation of mixing strategies and key parameters.

Scientific reports·2026
Same journal

A network analysis of personality traits, mentalizing, and psychological health in Chinese college students.

Scientific reports·2026
查看所有相关文章

相关实验视频

Updated: Jan 16, 2026

Design and Application of a Fault Detection Method Based on Adaptive Filters and Rotational Speed Estimation for an Electro-Hydrostatic Actuator
06:45

Design and Application of a Fault Detection Method Based on Adaptive Filters and Rotational Speed Estimation for an Electro-Hydrostatic Actuator

Published on: October 28, 2022

2.1K

对于非线性卡尔曼估计器的批量贝叶斯自动调整.

Cristovao Freitas Iglesias1, Miodrag Bolic2

  • 1School of Electrical Engineering and Computer Science (EECS), University of Ottawa, Ottawa, ON, K1N 6N5, Canada. cfrei096@uottawa.ca.

Scientific reports
|September 30, 2025
PubMed
概括
此摘要是机器生成的。

批量贝叶斯自动调整 (BAT) 通过使用所有数据进行调整来优化非线性卡尔曼估计器 (NKE). 这种新的方法提高了NKE在现实应用中的性能和可靠性.

更多相关视频

A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

14.2K
A Method for Tracking the Time Evolution of Steady-State Evoked Potentials
12:03

A Method for Tracking the Time Evolution of Steady-State Evoked Potentials

Published on: May 25, 2019

8.9K

相关实验视频

Last Updated: Jan 16, 2026

Design and Application of a Fault Detection Method Based on Adaptive Filters and Rotational Speed Estimation for an Electro-Hydrostatic Actuator
06:45

Design and Application of a Fault Detection Method Based on Adaptive Filters and Rotational Speed Estimation for an Electro-Hydrostatic Actuator

Published on: October 28, 2022

2.1K
A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

14.2K
A Method for Tracking the Time Evolution of Steady-State Evoked Potentials
12:03

A Method for Tracking the Time Evolution of Steady-State Evoked Potentials

Published on: May 25, 2019

8.9K

科学领域:

  • 控制系统工程 控制系统工程
  • 统计信号处理 统计信号处理
  • 计算生物学 计算生物学

背景情况:

  • 非线性卡尔曼估计器 (NKE) 需要精确调整五个关键参数以获得最佳性能.
  • 传统的NKE自动调整方法由于依赖于地面真实模型或部分数据而受到限制,导致效率低下和错误.
  • 手动调音耗时,容易出现人为错误,阻碍实际应用.

研究的目的:

  • 介绍一种新的自动调整方法,即批量贝叶斯自动调整 (BAT),用于优化非线性卡尔曼估计器 (NKE) 的所有组件.
  • 为了使所有可用的测量数据在NKE调过程中得到利用,克服现有方法的局限性.
  • 在实际场景中提高NKE估计的准确性,一致性和可靠性.

主要方法:

  • 开发了批量贝叶斯自动调整 (BAT),该方法使用所有可用的测量数据定义了所有NKE组件的全面后部分布.
  • 利用批量后置分布和递归贝叶斯推理之间的等价性在NKE的递归过程之外执行调整.
  • 使用合成生物工艺数据集验证了BAT方法.

主要成果:

  • 经验验证表明,与基线方法相比,BAT显著提高了NKE估计的一致性和准确性.
  • 与传统方法不同,BAT方法有效地利用所有可用的测量数据进行调整.
  • BAT成功优化了所有五个关键的NKE组件,包括过程噪声共变量,测量噪声共变量,初始状态噪声共变量,初始状态条件和动态模型参数.

结论:

  • 批量贝叶斯自动调整 (BAT) 为优化非线性卡尔曼估计器 (NKE) 提供了强大而高效的解决方案.
  • 该方法通过在调整阶段实现全面数据利用来提高NKE的性能.
  • 最佳技术为提高NKE在各种领域的可靠性和实际应用性提供了显著的进步.