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通过小鼠后壁皮层皮层中的刺激变异性对正负预测错误的微分调制
Benjamin Leonardon1, Sergej Kasavica1, Constanze Raltschev1
1Department of Physiology, University of Bern, Bern, Switzerland.
Communications biology
|September 30, 2025
概括
环境的不确定性塑造了我们的大脑如何更新内部世界模型. 这项研究揭示了变性如何调节单个神经元中的预测错误信号,突出了抑制的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 认知科学 认知科学
背景情况:
- 大脑不断更新它对世界的内部模型,以在不确定的环境中进行导航.
- 感官预测错误是这些更新的拟议机制.
- 以前的脑电图 (EEG) 研究表明,环境的不确定性会影响预测错误的神经相关性.
研究的目的:
- 研究环境不确定性如何调节单个神经元水平的预测错误反应.
- 探索在感官处理过程中后壁皮质皮质变异性的作用.
主要方法:
- 醒着的头部住的小鼠被暴露在听觉和触觉刺激中,可预测性各不相同.
- 采用双光子成像,记录神经活动在后壁皮质皮层的2/3层.
- 基于刺激强度偏差的积极和消极预测错误神经元的识别.
主要成果:
- 确定了积极和消极预测错误神经元的不同种群.
- 变量调高了正预测误差,调低了负预测误差.
- 计算建模表明,抑制神经元的可变性依赖调制最能解释观察到的神经反应.
结论:
- 环境的变化差异性调节后壁皮质皮质的积极和消极感官预测错误.
- 抑制性神经回路在编码与不确定性相关的预测错误方面发挥着至关重要的作用.
- 这些发现表明了大脑如何处理不确定性的新机制.
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