全球意识状态的皮层连接,局部动态和稳定性相关联
Yun Zhao1,2,3, Naotsugu Tsuchiya4,5,6, Mario Boley1
1Department of Data Science and Artificial Intelligence, Faculty of Information Technology, Monash University, Clayton, VIC, Australia.
Communications biology
|October 1, 2025
概括
这项研究揭示了意识依赖于大脑的连接,特别是在身区域. 减少意识与稳定的大脑活动有关,为神经生物学机制提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 清醒意识取决于复杂的大脑过程,但其神经生物学调节尚未完全理解.
- 研究意识的神经相关物 (NCC) 对于理解大脑功能至关重要.
- 意识的改变状态为这些机制提供了一个独特的窗口.
研究的目的:
- 应用一种新的基于推理的框架来分析神经生理学变量及其与意识的关系.
- 通过时间序列分析识别全球意识的神经机制的相关性.
- 调查意识改变状态中区域间连接和皮层动态的作用.
主要方法:
- 在整个皮层模型上使用了一个基于推断的空间-时间解析框架.
- 采用了15名Xenon诱导麻醉的参与者的磁脑图 (MEG) 数据.
- 开发了相互连接的神经质量模型 (NMMs) 来推断随时间变化的神经生理变量和连接性.
主要成果:
- 在意识水平和区域间连接之间发现了显著的相关性,特别是在后顶部,后部和前额部区域.
- 结果表明,状网络脊柱对全球意识至关重要,挑战纯正的正面网络理论.
- 鉴定了后额头和头区域内特定的区域相关性,并将意识减弱与稳定皮质动态联系起来.
结论:
- 开发的框架为研究意识的神经生物学基础提供了一种新的,时间解决的方法.
- 区域间连接,特别是在等级网络中,在保持全球意识方面发挥着关键作用.
- 皮层动态的变化,如稳定,与意识的减少有关.
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